Some people are privy to the fact that using THC regularly (the chemical compound in marijuana responsible for the brain-altering effects in users) causes the body to build up a form of resistance to its influence. What this means is that the longer someone uses THC, the more doses of the compound they will need to get the same impact they used to get previously when using a lesser dose. If this is so, does it have any implication for CBD users also?
Does the regular use of CBD cause the body to develop a tolerance to the compound? Well, according to studies, protracted usage of CBD oil or CBD cannot cause the body to build up an understanding to the compound. Continuous use of CBD may cause what is known as ‘reverse tolerance.’ This means that the user would have to use even less of the compound to derive the same effect as before.
That being said, there are a couple of users who do report experiencing a tolerance build-up to the compound in using it to treat conditions like pain, anxiety, and sleep disorders. Some users also reported that taking a bit of a break from using CBD and then going back to take the original dose as before resulted in the compound being as active just as it was previously. CBD’s effects differ from one user to the other.
What is the research saying?
When it comes to the body building a tolerance to THC, researchers have found that it is because of the cannabinoid receptors in the brain that THC binds itself to. Studies on lab animals showed that a reduction of CB1 receptors positive correlates with protracted and regular use of THC. A group of researchers reached this exciting conclusion in 2012. The study showed how CB1 receptors increased in expression after the use of THC was halted for 4 weeks. This connotes the idea that one can reverse a build-up of tolerance to THC by refraining from using the compound for some time.
CBD, however, works a bit differently. As we have mentioned, using CBD regularly may result in reverse tolerance rather. This happens because unlike THC, CBD doesn’t bind to cannabinoid receptors. CBD interacts with these cannabinoids in very different ways to impact their behavior.
In a report titled, “Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke,” which was released in 2010, researchers had this to say, “In the past five years, an increasing number of publications have focused on the discovery of the anti-inflammatory, anti-oxidant, and neuroprotective effects of CBD.
In particular, CBD experts positive pharmacological effects in ischemic stroke and other chronic diseases, including Parkinson’s disease, Alzheimer’s disease, and rheumatoid arthritis. The cerebroprotective action of CBD is CB1 receptor-independent, long-lasting, and has potent antioxidant activity.” The conclusion of this report which is more likely to be of interest to you read, “Importantly, CBD use does not lead to tolerance.”
There was a published research review in 2017 titled, “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.”
Researchers of this study did well to group every available clinical data on the effects of CBD, its efficacy, and its safety. Aside from revealing the fact that CBD is as safe and effective as can ever be, there was no mention anywhere of subjects developing a tolerance to the compound
CBD may instead cause a reverse tolerance
There is evidence out there that even though continuous use of CBD does not cause the body to develop an understanding of the compound, it can cause a reverse tolerance for specific effects.
In 1981, a study was conducted on the efficacy of cannabinoids in reducing seizures in animals. The study showed development of tolerance to THC by the subjects who were administered the compound and expansion of reverse tolerance to CBD by those subjects who were administered the compound. Quite a number of parents also claim to witness this phenomenon in their epileptic kids who are administered CBD.
If anything at all, what you can take from these studies is that it is important to be consistent with an appropriate dosage of CBD as well as being attentive to how it affects your body. In the course of using CBD, you may find its effects growing stronger without upping your dosage levels. In that case, you may want to cut down on your dosage levels.