CBD comes in so many different forms like tinctures, edibles or vape liquids. The CBD product that you choose and the way you take it is what determines is bioavailability. Bioavailability is the percentage of a substance that enters the bloodstream after it has been processed by the body.
Factors that affect the bioavailability of CBD
Depending on the mode of ingestion, the bioavailability of one CBD product is likely to be different from the other. In this article, we will seek to answer the question, “What is the bioavailability of CBD?”
Regardless of the method that CBD is ingested, its bioavailability will be influenced by certain standard factors. For instance, the hydrophobic properties of CBD oil affect its bioavailability regardless of the method used. What this means is that the inability of CBD to dissolve in water but rather gather in fatty tissues reduces the percentage that gets into the bloodstream. This tends to reduce the bioavailability of CBD that comes in the forms of edibles and capsules.
Other factors like a person’s body weight and the quality of the product influence the active dosage of CBD aside from the bioavailability of the product.
One of the fastest ways to get CBD into your bloodstream is vaping it. Vaping is becoming popular among CBD users today because of its ease and simplicity.
“When inhaled, the CBD enters the lungs and passes through tiny air sacs called alveoli, which exchange carbon dioxide and oxygen between the bloodstream and the lungs. CBD moves through the thin walls of the alveoli and directly into the bloodstream,” researchers explained. It is thought that the bioavailability is as high as or even higher than 50%.
Taking CBD sublingually
Taking CBD orally or sublingually refers to placing drops of CBD oil beneath the tongue for about 60-90 seconds and then swallowing it. This allows the oil to be absorbed directly into the bloodstream through the mucous membranes. According to researchers, “Capillaries in the connective tissue diffuse the substance, which then enters the bloodstream. In this method, the substance bypasses the first-pass metabolism.”
Taking CBD edibles
Many CBD users today have come to fall in love with CBD edibles. CBD edibles come in various forms including gummies, cake pops, and a whole range of products. While many people love CBD edibles, it has one of the lowest percentages of bioavailability of all available methods.
According to researchers, “When consumed orally, CBD passes through the digestive system and circulates through the liver. The bioavailability of CBD is reduced during what is known as ‘first pass metabolism.’ When consumed, CBD is metabolized by the liver and in other sites such as the gastrointestinal tract, lungs, and blood. It reduces the amount of CBD that is present in the bloodstream.” When it comes to CBD edibles, bioavailability is thought to be as low as 4-20% even though the effects are thought to last much longer.